ABSTRACT
Introduction: Mosquito-borne diseases have historically affected communities, especially in tropical areas where mosquitoes and illnesses are endemic. Globalization, climate change, and increased travel have created ideal conditions for outbreaks of mosquito-borne diseases that could threaten the American health system and place a burden on the national economy, especially in southern states. Methods: The study adopts a quantitative cross-sectional design with a retrospective survey carried out using the Pollfish platform in June 2022. The data were analyzed using descriptive statistics and hierarchical multiple regression to assess the three hypotheses: (H1) Chikungunya awareness is related to sociodemographic factors;(H2) Wearing long sleeves and pants is related to (a) Chikungunya awareness and (b) information-seeking behaviors, when controlling for sociodemographic variables;(H3) Use of insect repellents is related to (a) Chikungunya awareness and (b) information-seeking behaviors when controlling for sociodemographic variables. Results: The results highlight the relationships between chikungunya's awareness, information-seeking behavior, and willingness to engage in protective behaviors. 45.91% of the participants mentioned not having heard about chikungunya, and 67.07% of respondents had sought information about mosquito-borne illnesses in the past, 55.9% have looked at the U.S. State Department's website for mosquito-borne diseases, 38.32% have visited the U.S. CDC website for information specifically about chikungunya. Conclusions: The results of this study show that most American travelers are unaware of chikungunya and its mode of transmission. Travel could likely introduce the chikungunya virus to the United States. Despite increased health information-seeking behavior among U.S. residents after the Covid19 pandemic, Chikungunya awareness is low.
ABSTRACT
To analyze the population density, seasonal fluctuation of Aedes albopictus in Haizhu District, Guangzhou from 2017 to 2021, so as to provide a scientific basis for the monitoring and prevention and control of mosquito vector density of dengue fever. The data of dengue fever cases and Aedes surveillance data in Haizhu District, Guangzhou from 2017 to 2021 were collected, and the data of 2017-2019 and 2020-2021 were grouped to compare and analyze the characteristics of dengue epidemic and the density fluctuation of Aedes mosquitoes. A total of 517 dengue cases were reported in Haizhu District, Guangzhou from 2017 to 2021, of which only 7 cases were reported from 2020 to 2021, and the peak period of reported cases every year was August to November. Before the COVID-19 pandemic, there was a positive correlation between the number of local cases and the number of imported cases(rs=0.63, P<0.05) and BI(rs=0.73, P<0.05). The peak density of Aedes was from May to October, and the differences of mean BI(X~2=1 143.40,P<0.001), MOI(X~2=188.30,P<0.001), and SSI(X~2=4 499.43,P<0.001)before and after the COVID-19 pandemic were statistically significant. In general, before and after the COVID-19 pandemic, the density of Aedes in high-risk areas was higher than that in low-risk areas. After COVID-19 pandemic, the number of reported cases and the density of Aedes in Haizhu District decreased, but the density of Aedes in the high-risk area was still higher than that in low-risk areas, and a certain risk of outbreak still existed, so the government should continue to take more precise measures to strictly prevent dengue epidemic.
ABSTRACT
In January 2023, a total of 64 infectious diseases were reported globally, affecting 235 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (235), monkeypox (110), dengue fever (31), measles (27) and cholera (15). The top five infectious diseases with highest case fatality rates were Nipah virus disease (62.5%), Ebola virus disease (47.0%), Crimean-Congo haemorrhagic fever (37.5%), Lassa fever (15.1%) and West Nile fever (7.6%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, cholera, measles and dengue fever. The prevalent infectious diseases in Asia were COVID-19, cholera and dengue fever, the prevalent infectious diseases in Africa were COVID-19, cholera, yellow fever, Lassa fever, malaria and monkeypox, the prevalent infectious diseases in America were COVID-19, cholera, monkeypox, dengue fever and chikungunya fever, the prevalent infectious disease in Europe were COVID-19, monkeypox and invasive group A streptococcus infection.
ABSTRACT
Malaria is long known as a deadly vector borne infection, caused by five parasite species of the coccidian genus Plasmodia that are present in as many as 85 countries. Despite significant progresses have been achieved to control the infection by early diagnosis and artemisinin combination treatment, insecticide-treated nets and indoor residual spraying, malaria still represents a major public health issue in many endemic low-income countries. New diagnostic tools of higher sensitivity and specificity are now available for use in endemic countries to better guide diagnosis and treatment. In particular, highly sensitive rapid antigenic tests are now available and the loop-mediated isothermal amplification is a very promising and highly sensitive diagnostic tool. After 2015, decreasing morbidity and mortality trends have been stagnating because of limited funding, emergence of parasite and vector resistance to drugs and insecticides respectively and, recently, by the disrupting effect of COVID-19 pandemic. The incomplete knowledge of the complex immunity of malaria infection has slowed the development of an effective vaccine. However, in 2021, the RTS-S vaccine, however of suboptimal protective efficacy, has been made available for routine use in children above 5 months of age. Population movements has increased the chance of observing imported malaria in non-endemic areas, where malaria competent vectors may still exist.
ABSTRACT
Objective: To analyze the laboratory indexes of patients infected with malaria patients and COVID-19, so as to provide reliable evidence for the diagnosis of mixed infection of both. Methods The routine clinical laboratory items such as routine blood, biochemistry and lymphocyte subsets were tested in three cases of COVID-19 complicated with falciparum malaria who admitted to Guangzhou Eighth People's Hospital Affiliated to Guangzhou Medical University from July to December 2020 were tested. Laboratory data were stage-wise analyzed in conjunction with changes in the course of disease. Results Three patients confirmed COVID-19 infection recruited all had malaria infection history. Fever, headache, and other symptoms emerged on the 4rd to 11th day after admission. Malaria parasite was detected by malaria parasite antigen testing and blood smear testing, and all three patients had re-ignition of malaria after being confirmed COVID-19 infection. In the early stage of malaria relapse, lymphocytes decreased, CRP and SAA increased, and gradually returned to normal level after antimalarial treatment. Interestingly, we only found one patient at the initial stage of malaria detection showed PLT decreased, no other unnormal changes in other routine blood results (WBC, ESO) and liver function results (ALT, AST, GGT, TBIL, DBIL, CG) were found from the beginning to end course of the disease. Conclusion COVID-19 infection may promote the resurgence of malaria, so the relapse of malaria should be monitored especially for the patient with malaria infection history who begin to develop fever and other symptoms a few days after the diagnosis of COVID-19. The inflammatory indicators would be worth able as an auxiliary judgment basis for the effective treatment of the two combined infection.
ABSTRACT
Vaccination is effective in preventing the increase of disease, especially emerging infectious diseases (EIDs), and it is particularly important for people in close contact with infected sources and susceptible populations who are at increased risk of getting infectious diseases due to behavior, occupation or health. Despite targeted vaccination guidelines, inadequate vaccination of the key populations fails to receive widespread attention, resulting in a high-risk transition of disease from key populations to general populations. Strengthening the vaccination of the susceptible groups can effectively block the spread of pathogens to general populations, and reduce the consumption of medical resources in universal vaccination, which has significant economic value. In this review, we describe the prevalence of EIDs, analyze the experience and lessons of infectious disease vaccination in key populations through several cases, and further explore the causes for the decline in vaccination rates of key populations. According to the trends of EIDs, a plan to strengthen the vaccination of key populations is proposed to effectively prevent the transition of EIDs from key populations to general populations.
ABSTRACT
The molecular structure of hydroxychloroquine (HCQ) used in the treatment of malaria is recently suggested for emergency used in COVID-19. The chemical compound of HCQ is produced by chemical alteration of ethylene oxide from human products, such as waxy maize starch. The molecular graph is a graph comprising of atoms called vertices and the chemical bond between molecules is called edges. A topological index is a numerical representation of a chemical structure which correlates certain physico-chemical characteristics of underlying chemical compounds besides its numerical representation. To distinguish the creation of entropy-based measures from the structure of chemical graphs, several graph properties have been utilized. For computing the structural information of chemical graphs, the graph entropies have become the information-theoretic quantities. The graph entropy measure has attracted the research community due to its potential application in discrete mathematics, biology, and chemistry. In this paper, our contribution is to explore graph entropies for molecular structure of HCQ based on novel information function, which is the number of different degree vertices along with the number of edges between various degree vertices. More precisely, we have explored the degree-based topological characteristics of hydroxyethyl starch conjugated with hydroxychloroquine (HCQ-HEC). Also, we computed entropies of this structure by making a relation of degree-based topological indices with the help of information function. Moreover, we presented the numerical and graphical comparison of the computed results.
ABSTRACT
There are some doubts about the exact relationship between neglected infectious diseases (NIDs) and COVID-19 disease, which remains to be clearly defined. The present review summarized the effect of parasitic infections as the risk factors or protective agents in the COVID-19 pandemic. Parasites could proficiently modulate immune responses. Thus, parasitic infections could have a different impact on the incidence and clinical severity of COVID-19 in different regions of the world. Also, restoring programs to prevent, treat, and control NIDs, in particular helminths, could help in reducing the incidence and mortality of COVID-19 in endemic areas and help to increase vaccination effectiveness. Changes in the gut microbiome associated with helminth infection may have systemic immunomodulatory effects toward suppressing host immune responses, reducing vaccine efficacy and increasing the severity of other infectious diseases. The cytokine storm observed in severe cases of COVID-19 is characterized by a predominance of proinflammatory cytokines, such as IL-6. However, it is possible that helminth infection could change the outcome of infection by modifying the Th2 response to limit the inflammatory component;this would be particularly apparent in areas endemic for helminthic infections, which suggests a possible protective effect against COVID-19. Because parasitic infections affect more than 2 billion people throughout the world, their impact on COVID-19- associated effects on public health could be considerable. Further studies with larger sample sizes would be needed to explore the possible role of neglected parasitic infections in the COVID-19 pandemic.
ABSTRACT
Malaria is an endemic disease in a true sense. It is an acute febrile disease caused due to the parasite Plasmodium. However, unlike COVID-19, it failed to raise an international concern or gain the scientific limelight. Most of the 200 million globally affected by malaria, half of them are from Africa. Four of the nations, Nigeria (25%), the Democratic Republic of the Congo (11%), Mozambique (5%), and Uganda (4%), account for half of the world's malaria burden and is the leading cause of illness and death. In 2019, an estimated 5-6 million people died of malaria - most of them are young children in sub-Saharan Africa. Many of the countries affected by malaria have the lowest economic status. In the malaria-endemic region, the most vulnerable groups are young children and pregnant women. The costs of malaria are enormous to individuals, families, communities, societies, and nations. After a struggle for three decades, the much-awaited malaria vaccine, RTS, S (brand name Mosquirix), was finally launched;but it came with its controversies and allegations. This review explored the different angles of this disease, the vaccine development, and the emerging debates.
ABSTRACT
BACKGROUND: Immunity to mosquito salivary proteins could provide protection against multiple mosquito-borne diseases and significantly impact public health. We evaluated the safety and immunogenicity of AGS-v PLUS, a mosquito salivary peptide vaccine, in healthy adults 18-50 years old. METHODS: We conducted a randomized, double-blind, placebo-controlled Phase 1 study of AGS-v PLUS administered subcutaneously on Days 1 and 22 at the Center for Vaccine Development and Global Health, Baltimore, MD, USA. Participants were block randomized 1:1:1:1:1 to two doses saline placebo, two doses AGS-v PLUS, AGS-v PLUS/ISA-51 and saline placebo, two doses AGS-v PLUS/ISA-51, or two doses AGS-v PLUS/Alhydrogel. Primary endpoints were safety (all participants receiving ≥1 injection) and antibody and cytokine responses (all participants with day 43 samples), analysed by intention to treat. FINDINGS: Between 26 August 2019 and 25 February 2020, 51 participants were enrolled and randomized, 11 into the single dose AGS-v PLUS/ISA-51 group and ten in other groups. Due to COVID-19, 15 participants did not return for day 43 samplings. Participants experienced no treatment-emergent or serious adverse events. All solicited symptoms in 2/10 placebo recipients and 22/41 AGS-v PLUS recipients after dose one and 1/10 placebo recipients and 22/41 AGS-v PLUS recipients after dose two were mild/moderate except for one severe fever the day after vaccination (placebo group). Only injection site pain was more common in vaccine groups (15/51 after dose 1 and 11/51 after dose 2) versus placebo. Compared to placebo, all vaccine groups had significantly greater fold change in anti-AGS-v PLUS IgG and IFN-É£ from baseline. INTERPRETATION: AGS-v PLUS had favourable safety profile and induced robust immune responses. Next steps will determine if findings translate into clinical efficacy against mosquito-borne diseases. FUNDING: UK Department of Health and Social Care.
ABSTRACT
In May 2022, a total of 66 infectious diseases were reported globally, affecting 233 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (233), monkeypox (36), dengue fever (31), measles (24) and cholera (11). The top five infectious diseases with highest case fatality rates were Ebola virus disease (100.0%), Middle East Respiratory Syndrome (34.4%), Crimean-Congo hemorrhagic fever (22.2%), Lassa fever (19.8%) and monkeypox (4.0%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, cholera, dengue fever and measles. The prevalent infectious diseases in Asia were COVID-19, dengue fever and cholera, the prevalent infectious diseases in Africa were COVID-19, Ebola virus disease, cholera, yellow fever, Lassa fever, malaria and monkeypox, the prevalent infectious diseases in America were COVID-19, dengue fever, chikungunya fever and Zika virus disease, the prevalent infectious disease in Europe were COVID-19, monkeypox and acute hepatitis of unknown aetiology.
ABSTRACT
This article reported an astounding drop in dengue risk in 2020 attributable to public health and social measures during the pandemic. Taking population immunity into account, this study acknowledged how the unprecedented dengue burden of 2019 might have driven high immunity to dengue in 2020. This study also mentioned idiosyncrasies in the model that could not be explained. Moreover, it also adds possible considerations of (1) administrative delays and (2) genotype-replacement events driving the 2019 epidemics affecting conclusions drawn from the model. Therefore, the greatest dengue year on record in 2019, in terms of incidence, be treated as unique in that it was probably fuelled by viral evolutionary events resulting in genotype replacements and might falsely augment the differential dengue virus burden between a higher-than-usual 6-year mean dengue incidence (inclusive of 2019) versus the comparison year of 2020. From an academic standpoint, this study would be curious to see how the model would perform if the outlier year of 2019 were removed.
ABSTRACT
This article is based on a recommendation from an ongoing pilot programme in Ghana, Kenya and Malawi that has reached more than 800,000 children since 2019, with key findings: (1) The vaccine introduction is feasible, improves health and saves lives, with good and equitable coverage of RTS,S seen through routine immunisation systems. This has occurred even in the context of the COVID-19 pandemic, (2) RTS,S has increased equity in access to malaria prevention, with data from the pilot programme showing that more than two-thirds of children in the three pilot programme countries, who do not sleep under a bednet, have benefitted from the RTS,S vaccine, (3) To date, more than 2.3 million doses of the vaccine have been administered in three African countries, with a favourable safety profile, (4) In areas where the vaccine has been introduced, there has been no decrease in the use of insecticide-treated nets, uptake of other childhood vaccinations, or health seeking behaviour for febrile illness, (5) A reduction of 30% in deadly severe malaria, even when introduced in areas where insecticide-treated nets are widely used and there is good access to diagnosis and treatment, and (6) Modelling estimates that the vaccine is cost-effective in areas of moderate to high malaria transmission. Therefore, this recommendation includes funding decisions from the global health community for broader rollout, and country decision-making on whether to adopt the vaccine as part of national malaria control strategies.
ABSTRACT
Over the last decade many large world cities have scaled up efforts at climate adaptation, a primary focus of which is protecting population health. With extreme weather disasters increasing worldwide, public health agencies are among local institutions under greatest stress;the Covid-19 pandemic has only heightened pressure on these agencies. Yet the limited literature examining adaptation actions across world cities suggest few, mainly high-income cities report health-related adaptation, while city public health agency engagement in adaptation has received little research attention. In this comparative review, we aimed to characterize the public health role in the adaptation plans of 22 large cities pre-identified as highly health-adaptive, by examining five health-associated adaptation activities chosen as "promising practice" based on evidence synthesized from evaluation research and practical experience: (i) hazard and vulnerability mapping;(ii) extreme weather preparedness and response;(iii) extreme heat plans (including heat early warning);(iv) non-heat early warning (e.g., flooding, vector-borne disease);and (v) climate-health monitoring and outcome surveillance. We found most (90%) city adaptation plans reported actions in at least three of these five activity areas. However, only 73% of these health-focused plans reported involvement of a public health agency (though the share was higher for cities in low- and middle-income countries). We detected differences across the five activities, including an ascending pattern of public health engagement starting with heat plans and including activities such as preparedness and mapping as health agency involvement increased. We also identified substantial presence of other city agencies-notably urban planning, emergency management and public utilities-in implementing these health-associated activities. With every world region likely to experience more widespread and intensifying climate impacts, and growing pressure on local public health agencies in conjunction with the Covid-19 pandemic, we identify opportunities for enhancing public health engagement in climate adaptation in large cities with a view to scaling up their ability to contribute to climate adaptation goals.
ABSTRACT
This article provides a brief overview of the 31st meeting of the International TaskForce for Disease Eradication (ITFDE) that was convened at The Carter Center in Atlanta, GA, USA on 20-21 October 2020 to discuss "The impact of the COVID-19 pandemic on eradication and elimination programmes and the way forward." It highlights the results of 7 eradication programmes, with specific conclusions and recommendations for each: Guinea Worm Eradication Programme(dracunculiasis;GWEP);Global Polio Eradication Initiative (GPEI);elimination programmes for measles and rubella (MR), malaria, river blindness (onchocerciasis;RB), and lymphatic filariasis (LF);and the program for the Global Elimination of Trachoma.
ABSTRACT
In March 2022, a total of 63 infectious diseases were reported globally, affecting 230 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (230), dengue fever (32), measles (29), chikungunya fever (10) and cholera (9). The top five infectious diseases with highest case fatality rates were Crimean-Congo haemorrhagic fever (33.3%), Rift Valley fever (20.0%), Lassa fever (18.6%), yellow fever (11.3%) and monkeypox (5.5%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, measles, cholera and Lassa fever. The prevalent infectious diseases in Asia were COVID-19 and dengue fever, the prevalent infectious diseases in Africa were COVID-19, cholera, yellow fever, Lassa fever, malaria, measles and poliomyelitis, the prevalent infectious diseases in America were COVID-19, dengue fever and chikungunya fever, the prevalent infectious disease in Europe was COVID-19.
ABSTRACT
Increased globalization and international transportation have resulted in the inadvertent introduction of exotic mosquitoes and new mosquito-borne diseases. International airports are among the possible points of entry for mosquitoes and their pathogens. We established a mosquito and mosquito-borne diseases monitoring programme at the largest international airport in Austria and report the results for the first two years, 2018 and 2019. This included weekly monitoring and sampling of adult mosquitoes, and screening them for the presence of viral nucleic acids by standard molecular diagnostic techniques. Additionally, we surveyed the avian community at the airport, as birds are potentially amplifying hosts. In 2018, West Nile virus (WNV) was detected in 14 pools and Usutu virus (USUV) was detected in another 14 pools of mosquitoes (minimum infection rate [MIR] of 6.8 for each virus). Of these 28 pools, 26 consisted of female Culex pipiens/torrentium, and two contained male Culex sp. mosquitoes. Cx. pipiens/torrentium mosquitoes were the most frequently captured mosquito species at the airport. The detected WNV strains belonged to five sub-clusters within the sub-lineage 2d-1, and all detected USUV strains were grouped to at least seven sub-clusters among the cluster Europe 2; all strains were previously shown to be endemic in Austria. In 2019, all mosquito pools were negative for any viral nucleic acids tested. Our study suggests that airports may serve as foci of arbovirus activity, particularly during epidemic years, and should be considered when designing mosquito control and arbovirus monitoring programmes.
Subject(s)
Culex , Nucleic Acids , West Nile Fever , West Nile virus , Airports , Animals , Austria/epidemiology , Birds , Female , Flavivirus , Male , West Nile Fever/epidemiology , West Nile Fever/veterinary , West Nile virus/geneticsABSTRACT
The epidemiological data were collected from travellers who returned from Guinea on the 23rd of September, 2020 and were diagnosed with malaria at a COVID-19 quarantine site in Qingdao, Shandong Province. The epidemiological characteristics, diagnosis and treatment of the cases and the epidemiology investigation and the rapid test screening results for other travellers on from the same flight and the interventions in reaction to the imported malaria cases were analyzed. The results showed that 4 out of 231 Guinean returned travellers had developed malaria symptoms, including chills and fever, during the isolation period. Rapid diagnostic test (RDT) indicated Plasmodium falciparum infection. Considering the patients' travel history, clinical manifestations, and laboratory RDT test results, a confirmed diagnosis of imported P. falciparum malaria was made. The four malaria cases, who are male workers aged 29 to 55, were transferred to Jiaozhou People's Hospital for treatment. All four patients were administrated of artemether tablets upon diagnosis. One of the cases experienced severe malaria complications and were administrated with 12 doses (60 mg/dose) of artesunate intravenously for five days. The other three patients were treated with dihydroartemisinin and piperaquine phosphate tablets for one course of 8 tablets in 2 days (40 mg dihydroartemisinin and 320 mg piperaquine phosphate), respectively. Among the 231 returned travellers, 111(48.1%) had a history of malaria overseas. There were 23 positive cases detected by RDT, including the four symptomatic cases. The other 19 cases were asymptomatic. One of the asymptomatic cases became symptomatic three months later and was diagnosed as an imported P. malariae infection. Laboratory blood smear microscopic tests at the Jiaozhou City and Qingdao Municipal Center For Disease Control and Prevention showed negative results for the four malaria cases and the 19 RDT positive case. The samples from the four malaria cases were rechecked by the provincial reference laboratory of Shandong Institute of parasitic Disease. The results were negative for malaria infection by microscopic examination but positive for P. falciparum infection by nucleic acid test. It is suggested that during the routine control of COVID-19, the awareness of COVID-19 and malaria should be established among the returned travellers from high malaria-endemic areas. The health education "gate" should be moved forward to improve the treatment compliance for malaria cases and reduce the relapse or recrudescence caused by sub-optimal treatment.
ABSTRACT
Aim & objective: Study of incidence of malaria, Dengue and Chikungunya fevers among febrile patients visiting tertiary care hospital (King George hospital) in Visakhapatnam. Method: The study is conducted in-patients visiting King George Hospital, which is a Government General Hospital located in Visakhapatnam, Andhra Pradesh, India. The hospital with 1237 beds serving the needs of north coastal Andhra Pradesh and adjacent Orissa for more than 150 years. Patients presenting to the health centre with some signs and symptoms compatible with the diagnosis of malaria, dengue and chikungunya (fever which can be recent or in evidence during the previous 2-4 days or/and other symptoms of febrile diseases such as chills, headache, joint, muscle and body pains).100 febrile patients shall be selected randomly at the age group of 13-60 years Patients shall also be selected on the basis of febrile and other symptoms such as chills, headache, joint, and muscle and body pains. Results and Conclusion: Age wise Distribution of Malaria, Dengue and Chikungunya, number of patients n=100 were taken, total n=72 patients were positive for Malaria, n=24 patients were positive for Dengue and n=4 patients were Chikungunya. With the Mean of 10.6 and Standard Deviation are 6.1. From the age group of "36 to 50"years n=28 number of patients positive for both males and females, form this total n=12 positive for malaria with the percentage of 16.6% and Females were n=16 with the percentage of 22.2%. From the age group "51 to 65"years n=8 number of patients positive for malaria in both males and females, from this total the male patients were n=4 positive for malaria with the percentage of 5.6%. The age wise description of Dengue a total "n=24"number of patients are positive for Dengue in both males and females. From the total n=16 number of male patients which are positive for Dengue with the percentage of 66.6% with the Mean of 5.3 and Standard Deviation is 4.7.females were n=8 number of patients with the percentage of 33.3% and in the Mean of 11.1 with Standard Deviation is 2.4. The age wise description of Chikungunya fever of different age groups a total "n=4"number of patients are positive for Chikungunya fever in both males and females. From the total n=02 number of male patients which are positive for malaria with the percentage of 50% with the Mean of 0.6 and Standard Deviation is 0.5 females were n=02 number of patients with the percentage of 50% and in the Mean of 0.6 and Standard Deviation is 0.5. Chikungunya fever in both males and females, from the total male patients were n=0 positive for Chikungunya fever and females were n=1 number of patients positive for Chikungunya with the percentage of 25%. The maximum peaks are observed equally in the age of 36 to 50 years age group. The Month wise Description of Malaria, Dengue and Chikungunya positive patients from the month of April 2017 to month of October 2017. To identify the seasonal variation of the disease, analysis of the data on monthly basis was done.